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The coiled-coil domain of glycosomal membrane-associated Leishmania donovani PEX14: cloning, overexpression, purification and preliminary crystallographic analysis
The glycosomal membrane-associated Leishmania donovani protein PEX14, which plays a crucial role in protein import from the cytosol to the glycosomal matrix, consists of three domains: an N-terminal domain where the signalling molecule binds, a transmembrane domain and an 84-residue coiled-coil domain (CC) that is responsible for oligomerization. CCs are versatile domains that participate in a variety of functions including supramolecular assembly, cellular signalling and transport. Recombinant PEX14 CC was cloned, overexpressed, affinity-purified with in-column thrombin cleavage and further purified by size-exclusion chro...
Source: Acta Crystallographica Section F - September 14, 2020 Category: Biochemistry Authors: Shakya, A.K. Pratap, J.V. Tags: Leishmania donovani coiled-coil domain PEX14 peroxisomes glycosomes research communications Source Type: research

One-Pot Synthesis of Novel Hydrazono 1,3-Thiazolidin-4-One Derivatives: Molecular Modelling, ADMET And Biological Evaluation of Anti-HIV And Anti-Tubercular Agents
CONCLUSION: From the novel synthesized molecules none of the molecule is as effective as standards for anti-HIV and anti-tubercular drugs and hence can be further explored for its potential activities. Furthermore, derivatization was made to achieve more potent compounds for anti-HIV and anti-tubercular drugs.PMID:35549861 | DOI:10.2174/1570162X20666220512163049
Source: Current HIV Research - May 13, 2022 Category: Infectious Diseases Authors: Mohammad Arif Pasha Sumanta Mondal Naresh Panigrahi Gauri Shetye Rui Ma Scott G Franzblau Yong-Tang Zheng Sankaranarayanan Murugesan Source Type: research

Comparison of in vitro Resistance of Wild Leishmania İsolates, Which are Resistant to Pentavalent Antimonial Compounds, Against Drugs Used in the Treatment of Leishmaniasis
Conclusion: It was determined that none of the selected resistant L. tropica isolates showed resistance to Amphotericin B and that was also shown statistically (p<0.05). The results of this study are important in guiding clinicians and researchers who conduct studies on drugs and search for new drug molecules. PMID: 32212583 [PubMed - as supplied by publisher]
Source: Turkish Society for Parasitology - March 19, 2020 Category: Parasitology Authors: Özbilgin A, Çavuş İ, Kaya T, Yıldırım A, Harman M Tags: Turkiye Parazitol Derg Source Type: research

Antileishmanial Evaluation of the Leaf Latex of Aloe macrocarpa, Aloin A/B, and Its Semisynthetic Derivatives against Two Leishmania Species.
Authors: Tewabe Y, Kefarge B, Belay H, Bisrat D, Hailu A, Asres K Abstract The currently available antileishmanial drugs are either toxic or too expensive for routine use in developing countries where the disease is most common. Local people in the Somalia region of Ethiopia use the leaves of Aloe macrocarpa Todaro for the treatment of malaria, jaundice, and skin diseases. In our ongoing search for new, efficient, and safe antileishmanial drugs, we investigated the leaf latex of Aloe macrocarpa and its acid-hydrolyzed product aloin A/B (1), as well as the semisynthesized derivatives of aloin A/B, namely, aloe-emodi...
Source: Evidence-based Complementary and Alternative Medicine - March 29, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Molecular Characterization of Aquaglyceroporine: A Novel Mutation in LmAQP1 from Leishmania major (MRHO/IR/75/ER).
Conclusion: The functional prediction of the protein encoded from LmAQP1 showed that the mentioned mutation could not affect the three-dimension structure, but it may modify the drug uptake potential of this important channel. Based on from LmAQP1 role, it seems to be an appropriate candidate for drug development. According to search through internet, this is the first report of LmAQP1 from L. major (MRHO/IR/75/ER). PMID: 31673266 [PubMed]
Source: Iranian Journal of Parasitology - November 2, 2019 Category: Parasitology Tags: Iran J Parasitol Source Type: research

The F1F3 Recombinant Chimera of Leishmania donovani-Nucleoside Hydrolase (NH36) and Its Epitopes Induce Cross-Protection Against Leishmania (V.) braziliensis Infection in Mice
Discussion NH36 is a conserved phylogenetic marker of the genus Leishmania (42), a vital enzyme for the metabolism of the DNA of the parasite (43) and a very potent antigen (32, 33, 35, 37–39, 44, 45). Accordingly, it is considered a strong candidate for the development of a cross-protective vaccine against both visceral and cutaneous leishmaniasis of mice and humans (35, 38, 39, 41). Having previously identified that the F3 domain of NH36 contains important epitopes involved in the CD4+ lymphocyte mediated protection against visceral leishmaniasis caused by L. (L.) infantum chagasi (38) and against cutaneous ...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Funtabulously Frivolous Friday Five 232
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 232. Readers can subscribe to FFFF RSS or subscribe to the FFFF weekly EMAIL Question 1: This week’s tropical case was on cholera. John Snow, the godfather of epidemiological medicine, showed that the pump on Broad Street in London was responsible for an outbr...
Source: Life in the Fast Lane - March 29, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five Bellevue Stratford Hotel black fever Broad Street cholera Dum-Dum fever Dumdum Henry Whitehead john snow Joseph McDade Kala-azar Killer fever Legionnaries disease Leishmania donovani leishmania infantum Source Type: blogs

The Ecto-5'nucleotidase/CD73 Mediates < em > Leishmania amazonensis < /em > Survival in Macrophages
In this study, the activity of CD73 induced by Leishmania amazonensis in infected macrophages has been investigated and correlated with parasite survival and infection in vitro. For this, the expression of CD39 and CD73, by flow cytometry, in murine peritoneal macrophages infected with metacyclic promastigotes of L. amazonensis has been analyzed. Our results showed that L. amazonensis-infected macrophages, unlike LPS-treated macrophages, increased CD73 expression. It was also noted that when CD73 enzymatic activity was blocked by α, β-methyleneadenosine 5'-diphosphate sodium salt (APCP), macrophage parasitism was signifi...
Source: Biomed Res - February 21, 2022 Category: Research Authors: Bijay Bajracharya Deena Shrestha Andr é Talvani Ricardo Gon çalves Lu ís Carlos Crocco Afonso Source Type: research

Production and Purification of polyclonal antibody against attenuated and wild type leishmania infantum in dogs.
In this study we produced and purified polyclonal antibody against attenuated and wild type leishmania infantum in dogs. Anti-leishmania in dog serums precipitated with ammonium sulphate. The IgG recovered from ammonium sulphate precipitation was subject to ion exchange chromatography (IEC) and the purity of IgG was confirmed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) under reduced condition. The purity of proteins were above 95% and then purified IgG was conjugated with FITC. We determined optimum titer of dog IgG by observation parasites under fluorescent microscope. The optimum dilution of ...
Source: Human Antibodies - March 18, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

HIV-Associated Disseminated Histoplasmosis and Rare Adrenal Involvement: Evidence of Absence or Absence of Evidence
Adrenal histoplasmosis and primary adrenal insufficiency are mostly described in immunocompetent patients. This particular tropism is attributed to the presence of cortisol within the adrenal gland, a privileged niche for Histoplasma growth. In French Guiana, disseminated histoplasmosis is the main opportunistic infection in HIV patients. Our objective was to search in our HIV-histoplasmosis cohorts to determine how frequent adrenal insufficiency was among these patients. Between January 1, 1981 and October 1, 2014, a multicentric retrospective, observational study of histoplasmosis was conducted. Patients co-infected by H...
Source: Frontiers in cellular and infection microbiology - March 15, 2021 Category: Microbiology Source Type: research

Efficacy of pentamidine-loaded chitosan nanoparticles as a novel drug delivery system for Leishmania tropica
In conclusion, PTN-CNPs effectively inhibited both forms of the L. tropica; however, its effect was more salient on promastigotes. This data indicates that the PTN-CNPs act as a target drug delivery system. However, further research is needed to support its efficacy in animal and human CL.PMID:36602209 | DOI:10.47665/tb.39.4.003
Source: Tropical Biomedicine - January 5, 2023 Category: Tropical Medicine Authors: R U Khan M Khan A Sohail R Ullah A Iqbal B Ahmad I U Khan A Tariq M Ahmad A Said S Ullah A Ali M U Rahman A Zaman H Bilal Source Type: research